In this continuation of our previous post, we will go over how to get proper methylation, and determining if methylation is an issue at all for you. For starters, genetic testing is helpful as it points out defects in genes like MTRR and MTHFR. Of course, this story is way more complicated than a couple of genes, but it helps to know what these are.

One of the key components of this cycle is folate. You can learn something about your folate needs by taking methyl folate. Some people really feel great when this is added to their routine. We recommend you begin with 800 micrograms and work up to maybe 2.5 mg per day. If you feel better, you have your answer. If you feel terrible, you have also learned something about your physiology.

So if methylation is so important, why would a person feel terrible after taking a methyl donor like methyl folate? The answer will most likely come from another set of genes related to neurotransmitter function, especially the COMT gene. The COMT is involved in neurotransmitter metabolism, especially dopamine, epinephrine and norepinephrine. If you are having issues with your COMT pathways, you will tend to have a buildup of dopamine, epinephrine and norepinephrine. If you add methyl B12 and methyl folate, the breakdown of these hormones and neurotransmitters will slow even further.

B12 supplementsHow might this look in a real person? This particular person has genetically slow COMT activity and now you add some methyl donors like methyl B12 (a common type used) and methyl folate (from a well-meaning doctor), they will tend to have a dopamine build-up making concentration and focus difficult and it might appear that they aren’t even trying. Some authority figure confronts this person because this person’s performance isn’t up to par causing a fear reaction and a resulting adrenaline rush. This person is now has excess epinephrine and norepinephrine along with elevated dopamine. They feel both tired and wired, at the same time. They are even less able to function and the cycle continues. Over time, high levels of these catecholamines can lead to a greater probability of tachycardia and high blood pressure.

Continuing our discussion of folate, what about folic acid? You will see this added to many multi-vitamins and supplements. Some people have little problem converting folic acid into a form your body can use but some people have problems with the four steps it requires to make the conversion to a useful vitamin. So folic acid added to a supplement may or may not be helpful, it just depends. Usually the folic acid is in small amounts so it is not a big deal, which is not a big help, but not a big hindrance either.

To find B12 supplements to try for your health concerns, shop online at today. Contact us to learn more!